DEFINITION 

Hyaluronic acid (HA) is a high-molecular-weight linear polysaccharide composed of repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) linked by β(1-3) and β(1-4) glycosidic bonds. The biopolymer is wide- spread in nature, having been identified in vertebrate soft tissues (e.g., skin, synovial fluid, and vitreous humor of the eye), cultured eukaryotic cell lines, and certain prokaryotes (21). In bacteria, particularly in Lancefield group A and C streptococci, HA is found in the form of a lavish extracellular capsule.

PRODUCTION 

Hyaluronic acid is extracted from cocks’ combs or obtained by fermentation from Streptococci, Lancefield Groups A and C. It is produced by methods of manufacture designed to minimise or eliminate infectious agents. When produced by fermentation of gram-positive bacteria, the process must be shown to reduce or eliminate pyrogenic or inflammatory components of the cell wall. The desodium salt treatment is carried out after separation and dehydration.

INCI NAME: Hyaluronic Acid

CAS NO.: 9004-61-9

Grade: 1% Liquid grade

CHARACTERISTICS:

1.     A white or almost white, very hygroscopic powder or a fibrous aggregate, sparingly soluble to soluble in water, practically insoluble in acetone, in ethanol and in ether. 

2.     It is produced by Streptococcus zooepidemicus and low molecule weight from natural raw materials throuth fermentation. 

3.     It has a stable molecular weight and has a good water retention property for stable skin. It has excellent performance in beauty and moisturizing.

SPECIFICATIONS:

Item	Standard
Appearance	Transparent Solution, Colorless
Glucuronic Acid	≥4.5mg/ml
Hyaluronic Acid	≥9.3mg/ml
Molecule Weight	≥1.0 Million Da.
ph	6.0-7.5
Kinetic Voscosity	1000-18000
Protein	≤0.1%
Heavy Metals	1000-18000
Transparency	≤0.002%
Bacterial counts	≤2ppm
Mold and Yeast	99.9%
Salmonella	10/g
Arsenic	10/g
Endotoxin level	≤0.5eu/mg
E.coli	None
Staphylococcus aureus	NMT 2ppm
Pseudomonas aeruginosa	Negative
S.Aureus	Negative
S.Apecies	Negative

APPLICATION: Addition of phenoxyethanol 0.4-0.5%

PACKAGE: 20kg/durm.