DEFINITION 

Hyaluronic acid (HA) is a high-molecular-weight linear polysaccharide composed of repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) linked by β(1-3) and β(1-4) glycosidic bonds. The biopolymer is wide- spread in nature, having been identified in vertebrate soft tissues (e.g., skin, synovial fluid, and vitreous humor of the eye), cultured eukaryotic cell lines, and certain prokaryotes (21). In bacteria, particularly in Lancefield group A and C streptococci, HA is found in the form of a lavish extracellular capsule.

PRODUCTION 

Hyaluronic acid is extracted from cocks’ combs or obtained by fermentation from Streptococci, Lancefield Groups A and C. It is produced by methods of manufacture designed to minimise or eliminate infectious agents. When produced by fermentation of gram-positive bacteria, the process must be shown to reduce or eliminate pyrogenic or inflammatory components of the cell wall. The desodium salt treatment is carried out after separation and dehydration.

INCI NAME: Hyaluronic Acid

CAS NO.: 9004-61-9

Grade: Comsetic grade

CHARACTERISTICS:

1.     A white or almost white, very hygroscopic powder or a fibrous aggregate, sparingly soluble to soluble in water, practically insoluble in acetone, in ethanol and in ether. 

2.     It is produced by Streptococcus zooepidemicus and low molecule weight from natural raw materials throuth fermentation. 

3.     It has a stable molecular weight and has a good water retention property for stable skin. It has excellent performance in beauty and moisturizing.

SPECIFICATIONS:

Item	Standard
Description	White powder
Particle size	100% pass through 80 mesh
pH	3.5-8.0
Transparency	≥99.0%
Loss on drying	≤8.0%
Bulk Density	0.10-0.60g/cm3
Protein	≤0.1%
Molecular weight(Da.)	1.0-1.5 Million Da.
Residue on Ignition	≤20.00 %
Heavy metals	≤10ppm
Arsenic	≤2ppm
Glucuronic acid	≥46%
Hyaluronic acid	≥95%
Endotoxin level	≤0.5eu/mg
Bacteria counts	≤10CFU/g
Mold & Yeast	≤10CFU/g
E.Coli	Negative
S.Aureus	Negative
S.Apecies	Negative

APPLICATION: Recommedatory volumes of usage: 0.08-1.2%

PACKAGE: 1kg/foil-bag. 25kg/durm.